What
is SPECT?
SPECT is short for single photon
emission computed tomography. As its name suggests (single photon emission)
gamma rays are the sources of the information rather than X-ray emission in the
conventional CT scan.
Introduction
Emission Computed Tomography is a
technique where by multi cross sectional images of tissue function can be
produced , thus removing the effect of overlying and underlying activity. The
technique of ECT is generally considered as two separate modalities. SINGLE
PHOTON Emission Computed Tomography involves the use single gamma ray emitted
per nuclear disintegration. Positron Emission Tomography makes use of radio
isotopes such as gallium-68, when two gamma rays each of 511KeV, are emitted
simultaneously where a positron from a nuclear disintegration annihilates in
tissue.
Brain Imaging
This figure is a transverse SPECT image
of the brain. The hot spots present in the right posterior region are seen
clearly using SPECT. SPECT examines cerebral function by documenting regional
blood flow and metabolism.
Positron
Emission Tomography (PET)
The distribution of activity in slices
of organs can be obtained in a more accurate way using PET. In the simplest PET
camera two modified sophisticated cameras called Anger cameras are placed on
opposite sides of the patient. This increases the collection angle and reduces
the collection times which are the limitations of SPECT .In PET,
radiopharmaceuticals are labeled with positron emitting isotopes. A positron
combines rather quickly with an electron. As a result the two gamma quanta are
emitted almost in opposite directions .In PET scanners, rings of gamma ray of
gamma ray detectors surrounding the patient are used. Each detector interacts
electronically with the other detectors in the field of view. When a photon
arrives within a short time frame, it is clear that a pair of quanta was
generated and that these were created somewhere along the path between the
detectors. Conventional PET tomography makes use of standard filtered back
projection techniques used in computed tomography and SPECT.
Back
Projection
The
main reconstruction step involves a process known as ‘Back Projection’. As the
original data was collected by only allowing photons emitted perpendicular to
the camera face to enter the camera, back projection smears the camera bin data
from the filtered sonogram back along the same lines from where the photon was
emitted from.
Conclusion
It is reasonable to speculate about a
constant by perhaps a slower rate of increase of clinical applications of
SPECT. It is safe to conclude that SPECT has reached the stage where it will be
a valuable and also an unavoidable asset to the medical world.